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Each mL of Circulate contains arginine HCl 100mg, niacinamide (vitamin B3) 10mg, pyridoxine HCl (vitamin B6) 10mg and taurine 5mg

The clinical endpoints of interest were: excessive daytime sleepiness, dissociative REM sleep manifestations: cataplexy, sleep paralysis, hypnagogic hallucinations, and early REM sleep (REM sleep naps, SOREMP)

The prescription of PA should be based on pain tolerance and should be gradual while pain levels are monitored [50, 104]

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