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It has been suggested that higher aerobic fitness levels are associated with larger hippocampal volume and improved neuronal health and that acute aerobic exercise can induce increased BDNF levels in the peripheral blood [179]

doi:10.1093/aje/kwm003

Although the precise etiology of the AD remains unclear, but its pathology is mainly defined by two hallmarks: The extracellular neurotoxic senile plaques composed of amyloid- (A) peptides, which are generated from the proteolytic cleavage of amyloid precursor protein (APP) by -site APP-cleaving enzyme-1 (BACE-1), and intracellular neurofibrillary tangles that are composed of tau protein filaments

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It is involved in a multitude of physiological processes such as photosynthesis, protein biosynthesis and respiration

Hum Reprod 10(1):5055 Schaeffer HJ, Sirotkin AV (1997) Melatonin and serotonin regulate the release of insulin-like growth factor-I, oxytocin and progesterone by cultured human granulosa cells