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Dose-response relationships appear to be tissue-specific, with adipose tissue showing high sensitivity while other tissues may require higher concentrations for detectable effects

Semaglutide and tirzepatide are injected once weekly

These injections are perfect for men who train hard, recover often and want to optimize both body composition and performance

doi: 10.1111/j.1365-2826.2009.01895.x

It makes it appropriate for a different use case: the person who already controls their diet, exercises consistently, and wants a modest additional push in fat mobilization without the gastrointestinal side effects, nausea, or hormonal disruption that come with GLP-1 agonists