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Abstract The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy have begun to receive considerable attention in recent years

cruzi infection (Poncini et al., 2008
Risk management frameworks, such as scenario analysis, stress testing, and Value-at-Risk (VaR) models, are integral to their decision-making processes
Peptides act as signaling molecules, essentially telling other molecules what to do

Key design elements: Population: 145 adults (18 years) with NF1 and at least one symptomatic, inoperable PN measurable by volumetric MRI, randomized 1:1 to selumetinib (n=71) or placebo (n=74) for 12 cycles Inoperability criteria: PN defined as inoperable due to encasement of or proximity to vital structures, invasiveness, or high vascularity Primary endpoint: Confirmed ORR by cycle 16, assessed by independent central review using Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) criteria, where response is defined as 20% reduction in PN tumor volume Results from KOMETs primary analysis, presented at ASCO 2025 and published in The Lancet , demonstrated: ORR 20% (14/71, 95% CI: 11.230.9) in the selumetinib arm vs

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