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In a study using an OVA-induced AR mouse model, N,N -dicoumarolespermidine reduced serum OVA-specific IgE production and the abundance of inflammatory cells in nasal lavage fluid

These effects could be ascribed to the antioxidant and free radical scavenging properties of both SE and AST, which is probably mediated, via donating electrons to free radicals, thus stabilizing them and changing them into inactive form , together with their ability to enhance antioxidant defense mechanisms (Gutirrez-del-Ro et al

Hence the net result of a cascade reaction of SOD and CAT is to convert 4 molecules of superoxide and four protons to 2 molecules of water and 3 molecules of molecular oxygen

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doi: 10.1128/iai.60.4.1499-1508.1992 61 HirakawaM
