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doi:10.1136/bjo.87.1.101 41

MCDD-induced suppression of mitochondrial and peroxisomal FAO was restored by statins

Preclinical studies have shown that hippocampal mRNA levels of interleukin-1beta (IL-1) and tumor necrosis factor-alpha (TNF-) are increased in a rat model of PTSD, and that substances ameliorating PTSD-related behaviors attenuate the elevation of hippocampal inflammatory cytokine mRNA 8,9

Accordingly, the ASCO and NCCN guidelines note that stimulants can be considered only for refractory CRF or when rapid improvement in fatigue is needed (e.g., to maintain work schedules), but they refrain from routine recommendation due to mixed evidence and potential side effects