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To reproduce the peptide-binding mode observed in hexapeptide complex I described above, DAP BII (H86A) and DAP BII (H86A/D224A/S657A) were crystallised with intact angiotensin IV (hexapeptide complexes II and III, Table S1)
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It inhibits enkephalin-degrading enzymes (enkephalinase/neprilysin), raising endogenous enkephalin tone, which contributes to stress resilience and emotional regulation
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