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NJT has consulted with Brown University and Agency for Health Care Research and Quality (fiber and laxation), outside the submitted work

[50] Structure and pharmacology [edit] Semaglutide is chemically similar to human GLP-1

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Whether GLP-1 receptor agonists also exert direct effects on immune cells is an area of ongoing preclinical and early clinical research, but this has not been established as a confirmed mechanism in NICE-approved treatment pathways and should be regarded as preliminary