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Thus, the maintenance and regeneration of SGNs and their synapse are critical for SNHL therapy

TRMs, Tissue-Resident Macrophages

doi: 10.4049/jimmunol.147.11.3815 [DOI] [PubMed] [Google Scholar] 180

Compared with protein replacement therapy, this dCas9 mRNA delivery system displays a broader pharmacokinetic curve of therapeutic protein with one single dose

The alternative orientations of the active site phenylalanyl versus tyrosyl residues, together with the different orientation of the GSH thiols, will also affect the attack of the second GSH on a Grx-GSH mixed disulfide intermediate, as this has to occur in an angle of 180 28

These free radicals are highly reactive toward polyunsaturated fatty acids, which are abundant in brain cellular membranes