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The effect of GHK or GHK-PEG on cytotoxicity, cell viability, and apoptosis in neuroblastoma cells For apoptosis assay, neuroblastoma cells, SH-SY5Y, were cultured in 96 well plates and treated with GHK or GHK-PEG at 1 and 10 nM for 24 hrs and assayed using the Apo-ToxGlo Triplex Assay by Promega

[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Zhang J, Motyl KJ, Irwin R, MacDougald OA, Britton RA, McCabe LR

( A ) Experimental design to assess the contribution of RpoS to persistence in C3H/HeJ and SCID mice (5 mice per condition, per time point)

Thymosin Beta-4 Heritage: Parent compound is endogenous and well-characterized Clinical Trials: RegeneRx trials showed generally favorable safety in ophthalmic and cardiac applications Cancer Concerns: Theoretical concerns about cell migration and tumor potential

A recent review summarizes safety gaps and the regulatory context in the FDA context

Mechanism of Action Regulation of immune system Stimulation of T-Cell Activity T-cells play an important role in immune surveillance