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However, increasing lipophilicity to improve brain penetration risks a dramatic reduction in solubility once in the aqueous environment of the brains interstitial fluid, and CNS-to-blood transporters further prevent drug accumulation within the brain [6]
[DOI] [PubMed] [Google Scholar] 15.Cerovecki T, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, et al
