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Kim Y.-I

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

On the other hand, the allelic distribution of KRAS mutations varies significantly among cancer types, reflecting different underlying mutational processes (for example, KRAS G12C association with smoking) and suggesting tissue-specific oncogenic signaling that varies among KRAS alleles, carrying differential sensitivity to targeted therapies [172,173]

doi: 10.1093/fampra/cmi021

Pyrczak-Felczykowska A, Reekie TA, Jkalski M, et al

In obesity, altered calcium metabolism and secondary hyperparathyroidism may further complicate vitamin D physiology, and combined calciumvitamin D supplementation has been shown in some trials to modestly influence adiposity and metabolic indices, although effects remain heterogeneous (161)