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Syst Rev (2012) 1:33

While caloric restriction alone often results in loss of both fat and muscle, AOD-9604 preferentially targets adipose tissue

Relief from fatigue, headaches or dehydration can appear more quickly compared with waiting for oral supplements to take effect over days or weeks
in high concentrations it provokes liver damage during cholestasis and promotes colon carcinogenesis in experimental animals[54,55]

That creates an interesting dynamic

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