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While NOX2 causes cardiac hypertrophy through angiotensin II, NOX4, which partially localizes to the mitochondria, is associated with cardiac hypertrophy due to increased pressure overload from myocardial stresses in the failing human heart

Understanding where you have a genetic susceptibility and then optimizing to avoid specific toxicants or drugs is the key here

The VDR is a member of the steroid and thyroid hormone superfamily of nuclear receptors

van der Schors, T., Amann, S., Makridaki, D., & Kohl, S

The journals of gerontology Series A, Biological sciences and medical sciences 2010;65, 1275-1284

S.RamanaK
