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In epilepsy, enhancing PKM2 expression through deubiquitination promotes astrocytic lactate production, improving local energy supply and reducing seizure frequency
3.4 Macrophage polarization modulation by Se/LDH@PEG-M Emerging evidence underscores the critical association between OA progression and disrupted M1/M2 macrophage polarization within synovial tissues, where excessive ROS accumulation serves as a key driver of pro-inflammatory M1 phenotype dominance [44]
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Bibcode:1968PNAS...59...94H
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