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Compared with those in normal skin fibroblast subpopulations, the expression levels of senescence- and inflammation-associated genes, including p16 (also known as CDKN2A ), SFRP4 18 , IGF1 19 , and IL1R1 were increased in keloid mesenchymal fibroblasts, whereas CCND2 , IL-6 , CXCL3 , and IL1R1 were increased in keloid pro-inflammatory fibroblasts (Fig

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Utilizing hiPSC-derived oligodendrocytes to study myelin pathophysiology in neuropsychiatric and neurodegenerative disorders

Keloid scars are similar but grow beyond the original wound boundaries, sometimes significantly larger than the initial acne lesion

Low hormones, poor circulation, or systemic inflammation can delay healing