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The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, protein binding, active metabolites, and receptor interactions

Heat is used to eliminate microbes and other contaminants from final product

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Liddle syndrome has low morbidity and uncommon clinical symptoms, and the diagnosis can only be confirmed by genetic diagnosis, which makes clinical studies of Liddle syndrome more difficult to conduct