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Intracellular production of OH from H 2 O 2 is driven by the Fenton reaction, shown in Reaction 3 (43, 44, 48): As the most reactive known ROS, OH reacts with nearly all intracellular building blocks and macromolecules (amino acids, nucleic acids, phospholipids, sugars, proteins, RNA, DNA, lipids, polysaccharides)

Pharmacologic treatment with antiepileptics and antidepressants in patients with co-occurring anxiety and depression and an early non pharmacologic approach based primarily on physical exercise could be a useful indication in current neurology clinical practice

Nutritionists and medical professionals should supervise the use of supplements and diets, as following a restricted diet might have other detrimental effects on ones health [14,19]

The conversion (%) of the substrate was confirmed by gas chromatography

By thoroughly investigating the systemic effects mediated by the carnitine pool, including its impacts on the liver, gut, kidney, muscle, heart, lung, and eye, we emphasize the importance of maintaining carnitine pool homeostasis for overall metabolic health and inter-organ metabolic cooperation