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299 (2), L150L159

Zhang Y, Zhang J, Wang S (2021b) The role of rapamycin in healthspan extension via the delay of organ aging

(2022) found that aminoglycosides bind to and trigger rapid translocation of Rho family interacting cell polarization regulator 2 (RIPOR2) in cochlear hair cells from the stereocilia to the pericuticular area, which interacts with the core autophagy component GABARAP and affects autophagy activation

They function primarily during mammalian development to establish DNA methylation patterns as epigenetic remodeling and reprogramming proceed during differentiation

Reduced glutamate uptake 278 and increased release of GABA 279 also affect synaptic transmission and plasticity, arguably contributing to the pathophysiology of depression

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