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The release in glutamate following hypoxia has been suggested to be due, at least in part, to a calcium-independent mechanism following the reversal of the neuronal glutamate uptake carrier [63]

Bayley EM, Zhou N, Mitchell KG, Antonoff MB, Mehran RJ, Rice DC , Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Cinciripini PM, Karam-Hage M, Roth JA, Hofstetter WL

A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication

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Additionally, the presence of Mg 2+ plays a crucial role in regulating the levels of "intracellular free Ca 2+ and intracellular pH"

doi: 10.1016/0006-291X(83)91796-5