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Pretreatment with SA (40 mg/kg/day) significantly mitigated colonic injuries and acetic acid-induced UC symptoms in rats, reducing oxidative stress (MDA, NO levels), restoring antioxidant/oxidant balance (catalase, glutathione levels), suppressing inflammation (TNF-, IL-6, MPO, PGE2, COX-2, NF-B), and inhibiting apoptosis (Bax, caspase-3), while increasing anti-apoptotic protein Bcl-2 expression [388]

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