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Keywords: GLP-1 receptor agonist, polycystic ovary syndrome, semaglutide, inflammation Introduction Polycystic ovary syndrome (PCOS), a common reproductive endocrine disease, affects approximately 610% of young women.1 Infrequent menstruation, ovulation disorders, hyperandrogenemia (HA), polycystic ovarian changes, and insulin resistance (IR) are the main characteristics of PCOS.2 The etiology of PCOS is complex, including hypothalamic and ovarian dysfunction, chronic inflammation, IR, obesity related mechanisms, and excessive exposure to androgens.3,4 Currently, diet adjustment, exercise intervention, and medication are the main treatment methods for PCOS

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