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Orgiazzi, A

Oxidative stress results from an imbalance between antioxidants and oxidants (i.e., radicals)

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Additionally, microbial fermentation products such as succinate participate in energy homeostasis regulation through the gut-brain axis (46)

Melanin synthesis in melanosomes undergoes two main phases, the first of which is the generation of L-dihydroxyphenylalanine (L-DOPA) from tyrosine catalyzed by the TYR and the further generation of dopaquinone (DQ) by the TYR, or the TYR-catalyzed tyrosine direct oxidation to produce DQ [12, 13]
