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In parallel, emerging data suggest that gut microbiota composition and its metabolites (notably short-chain fatty acids) display modest menstrual-phase-related variation and are associated with markers of dyslipidemia and dysbiosis, implying that microbiotahost interactions may further modulate lipid handling across the cycle, particularly in women with obesity or metabolic syndrome [121,126]

100 E155 deletion in GSTO1 impacts the enzymatic stability and leads to changes in the physiologic role of the enzyme in the brain regions