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Mitochondrial dysfunction linking obesity and asthma

In models of cachexia and chronic muscle atrophy, expression of the fission-related protein Fis1 is upregulated, whereas Mfn1/2 levels are decreased, implicating ROS in both transcriptional and post-translational regulation of mitochondrial dynamics (Powers et al., 2016)

When administered, it directly binds to toxic cyanide ions, forming harmless cyanocobalamin, which is then safely excreted in the urine

Res J Pharm Technol 14(1):555561 Wasim R, Mahmood T, Shamim A, Ahsan F, Singh A (2024) Metaphorical investigation of aqueous distillate of cichorium intybus , foeniculum vulgare and solanum nigrum along with Atorvastatin and Orlistat in experimental rodent models of dyslipidaemia and obesity