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The present study does not include histological image acquisition, nor a sperm count or morphology tests that are needed to fully to define the magnitude of HnB exposure on the spermatogenesis, especially considering that sperm adverse outcomes can occur as a result of short-term exposure ( Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors

CE is an active metabolite that displays pharmacological activity, with a longer average half-life (148 15 min) than cocaine [24]

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