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The process is dynamic, and involves also the thiolate groups of proteins such as serum albumin and haemoglobin and appears as the main mechanism for the distribution of thiol-binding metals from the absorption site throughout the body and towards the active sites where the toxic action is developed at the molecular level

J.KoefoedK.HeyA.PykeC.HaurumJ

In mammals, OS arises from either an overproduction of ROS or a reduction in antioxidant defense mechanisms [6]

Other limitations include the fact that the in vitro granuloma model used is not an exact replication of in vivo granulomas which have a more complex and dynamic environment containing other cells like fibroblasts, collagen matrix, and other white blood cells

Update on ischemia-reperfusion injury in kidney transplantation: pathogenesis and treatment

Furthermore, some ATZ particles can become airborne via volatilization and be redistributed through atmospheric deposition by rain 4