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The total cell counts and total protein concentration in BALF, indicators of cellular infiltration and increased alveolar permeability, respectively, were significantly elevated by LPS

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As drug development programs are fast approaching US$3 billion per FDA-approved drug, the consideration of a prodrug strategy early in development may be more efficient than attempting to save a problematic candidate later in the pipeline [6]

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Preclinical observations in animal and cell culture studies have included enhanced cellular migration, increased markers of angiogenesis, and enhanced collagen deposition

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