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JAMA Intern Med 176 , 14741481 (2016)

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The researchers monitored the effect of FOXO4-DRI on a group of aged laboratory mice, noting a significant decrease in the number of senescent Leydig cells and a parallel increase in the concentration of testosterone in the blood plasma

doi: 10.3390/nu7053094

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Without adequate methylation processes the individual cannot adapt or heal effectively and will suffer the delirious effects of accelerated aging (5)