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The third clinically used CDK4/6 inhibitor is ribociclib, which also shows potential pro-senescence effects [88]
Journal of Molecular Neuroscience 44: 611
Due to this symmetry mismatch, the bottom of ATD and top of the LBD domains of only the distal subunits are in close apposition and interact with each other unlike the ATD and LBD domains of the proximal subunits
