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Evidence from several animal studies suggests that gabapentin may lower blood pressure and heart rate by acting on key cardiovascular control centers in the brain, including the nucleus tractus solitarii (NTS), an important region involved in autonomic regulation

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The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]