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B12 also downregulated CSF2 ( P = 0.0071) and CXCL10 ( P = 0.0205) in leukocytes from impaired individuals, although these genes were not differentially regulated when compared to the non-impaired group

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Furthermore, these epithelial components express various surface receptors, including TLRs to sense endogenous danger signals, or pathogen-associated molecular patterns (PAMPs) to detect microbes