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It is worth noting that neutralizing antibodies frequency is lower for intramuscular interferon beta 1a (which has been associated with the lowest frequency of NAbs, 2% to 6%) (50
If a person meets the diagnostic criteria for cEDS, genetic testing should be done to confirm the diagnosis
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Furthermore, mutant p53 expressed in cancer cells has been reported to impact macrophage behaviour through its GOF effects thereby supporting tumour development [190]
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This modification increases molecular size, reduces renal clearance, and shields the peptide from enzymatic degradation [264]
