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Under the Biden administration, the Centers for Medicare and Medicaid Services (CMS) released a series of guidance documents (which were updated in 2024) on a new waiver opportunity to expand the tools available to states to address enrollee health-related social needs (or HRSN)

These include: Lithium, certain beta blockers such as Inderal, some heart medications such as Quinidine, antimalarial drugs, iodides, certain anti-inflammatories used to treat arthritis such as Indomehacin

Finally, recent studies have suggested that the oxidation of lipids (such as polyunsaturated fatty acids and cholesterol) generates electrophilic compounds that modify Lys residues in SOD1, inducing its aggregation (Dantas et al., 2020)

6.6.2.2 Synergistic attribution of the triple-defense mechanism The triple-defense mechanism illustrated in Figure 7 represents synergistic actions of both parent compounds and gut microbiota-derived metabolites, rather than singular attribution

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Krivic et al., 2008)