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These metabolites, particularly hydroxynorketamine, have been shown to possess pharmacological activity, including potential antidepressant effects

Another double-blind randomized controlled trial of 20 patients undergoing surgery for abdominal aortic aneurysm reported that N-acetylcysteine was associated with anticoagulant and platelet-inhibiting properties, with decreased prothrombin time and prolonged coagulation time (33)

Recently, it was shown that MRP1, 4, and 5 are expressed in the lens, and it was suggested that these proteins are important in the detoxification of potentially toxic metabolites via excretion of the corresponding glutathione S -conjugates (Umapathy et al., 2015)

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Doorn, J., Moll, G., Le Blanc, K., van Blitterswijk, C

doi: 10.1152/ajpendo.1999.276.3.e558