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In contrast, 10 studies investigated the relationship between B12 supplementation status and homocysteine levels, encompassing a total of 191 participants (mean: 19.1 per study)

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After grouping sequences into arbitrary OTUs, amplicon sequence variant (ASV), or bins (specific for metagenomic sequencing), statistical methods are used to identify the diversity within and amongst samples or sample groups

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Although the serum MMA concentration reflects an intracellular cobalamin deficiency, other causes of elevated MMA must be considered, such as renal failure, reduced plasma volume reduction, and abnormalities in hepatic methyl-malonyl CoA mutase activity [15,47]

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10.1097/brs.0b013e3181a3967f 2 AkedaK.OhishiK.TakegamiN.SudoT.YamadaJ.FujiwaraT.et al (2022)

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