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Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements

Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity

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Effects of NNMT inhibitors on lipogenesis and intracellular levels of metabolites, including NNMT reaction product 1-methylnicotianamide (1-MNA) were evaluated in cultured adipocytes

If mild discomfort such as insomnia occurs during use, discontinue use and adjust the dosage promptly to ensure safety

In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression