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Testing before and during therapy helps refine dosage and timing

182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

Activation of canonical Wnt signalling is required for TGF--mediated fibrosis

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Effect deepens as the dose climbs

(2017) 8:e2820