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12, 16, 18 A high degree of synergistic enhancement of L-PAM cytotoxicity in the presence of BSO was observed in multidrug-resistant neuroblastoma cell lines, including those that were established at relapse after myeloablative therapy with L-PAM and lines highly resistant to L-PAM due to loss of p53 function, especially at concentrations of L-PAM that were myeloablative

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Such responses promote the infiltration of leukocytes, the pro-inflammatory effects of neutrophils, and the activation of complement and platelets, leading to the disruption of the BBB [72]

Franois K, Bargman JM