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However, insulin resistance has been reported for other mouse models with extended longevity, including Klotho transgenic mice [34], IRS1 / mice [37] and mice with a brain specific deletion of IRS2, which are long-lived when fed a high fat diet [38]

The interactome study is based on forward and reverse pull-downs that may underrepresent micromolar interactions

doi: 10.1016/s0891-5849(99)00041-6

The transduction signalling mediated by IgG1 immune complexes are known to promote a concomitant production of superoxide and nitric oxide leading to the production of peroxynitrites and cell death by apoptosis

[DOI] [PubMed] [Google Scholar] 86.Misra U.K., Kalita J., Singh S.K., Rahi S.K

M.ShultsE