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First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design

It is derived fragment of human growth hormone (fragment 176-191) known mainly for its lipolytic qualities, which in research have been associated with the stimulation of body fat metabolism without the negative side effects mainly reported with common weight loss drugs

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

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When we consider alcohol's impact on these nutrients, the picture becomes even more concerning
