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doi: 10.3390/ijms26136310

Editor: Sheng-Nan Lu, Chang Gung Memorial Hospital Kaohsiung Branch, TAIWAN Received: September 1, 2016

In blood plasma, Cu binds to ceruloplasmin, a transport protein that is a reactive protein of the acute phase

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The strong interaction between HIF-1 and VEGF rapidly activates angiogenic cascades, accelerating tumor angiogenesis ( 3 Mechanism of copper-induced regulated cell death Regulated cell death (RCD), also known as programmed cell death, is a highly controlled process that occurs in multicellular organisms