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In the same way, it has been postulated that majority of these cardiovascular events related to low IGF-I levels may be due to a possible insulin resistance and accelerated atherosclerosis[296]

An impaired CD4 + T cell response has been suggested to be a hallmark of severe COVID-19 (refs

4), acting at multiple levels of both innate and adaptive immunity [123]

Biomed Pharmacother 163:114822 Pesch AM, Pierce LJ, Speers CW (2021) Modulating the radiation response for improved outcomes in breast cancer

This mechanism ensures precise drug delivery to tumor cells, minimizing nonspecific drug release and reducing off-target effects [146]