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Furthermore, RGTTCRA-tRFs complementarity to ribosomal RNA and the translation-supporting LeuCAG3-tRF might aggravate PD via translational inhibition, as reflected by disrupted ribosomal association of RGTTCRA-tRFs in depolarized neuroblastoma cells
However, its limited bioavailability in humans due to poor intestinal absorption, rapid metabolism, and rapid systemic elimination remains a significant challenge
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The lamotrigine used by the first patient could not provide reliable symptom control
