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[14] According to the classical A-F system, GPCRs can be grouped into six classes based on sequence homology and functional similarity: [15] [16] [17] [18] Class A (or 1) (Rhodopsin-like) Class B (or 2) (Secretin receptor family) Class C (or 3) (Metabotropic glutamate/pheromone) Class D (or 4) (Fungal mating pheromone receptors) Class E (or 5) (Cyclic AMP receptors) Class F (or 6) (Frizzled/Smoothened) More recently, an alternative classification system called GRAFS (Glutamate, Rhodopsin, Adhesion , Frizzled/Taste2, Secretin) has been proposed for vertebrate GPCRs

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[DOI] [PubMed] [Google Scholar] 5.Arnold DL, Bore PJ, Radda GK, Styles P, and Taylor DJ

Inflammation and Immunomodulation Octadecanoids, like other oxygenated fatty acids including eicosanoids and docosanoids, are involved in the regulation of inflammatory processes, with both pro- and anti-inflammatory activity

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