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Figure 3 4.1 Inhibition of mitochondrial function and oxidative phosphorylation Mitochondria are organelles chiefly responsible for oxidative phosphorylation, converting oxygen and nutrients into cellular energy

Adv Protein Chem 45 , 153203 (1994)

Thompson met that criteria

However, while HDAC6 inhibition reduced oxidative damage and preserved cartilage in mouse models and TBHP-treated chondrocytes, the spontaneous and slowly progressive nature of human osteoarthritis is not fully captured in these systems

Notably, mitochondrial Trx2 contains the active site motif found in Trx1 but lacks additional structural cysteines, proposed to modulate its function as regulatory sites [11,12]