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Another theory suggests that the intellectual impairment is caused by the accumulation of phenylalanine in the brain, which becomes a major donor of amino groups in aminotransferase activity and depletes neural tissue of 2-oxoglutarate (-ketoglutarate)
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Instead, it is a combination of diet and environment, which interacts with increased susceptibility due to the MTHFR variants
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At present, most of the extensively studied HDAC inhibitors or SIRT agonists have broad-spectrum effects
