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They are oral, regulated as supplements rather than injectables, and considered low risk
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4-HNE: 4-hydroxynonenal
It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)
10.18632/oncotarget.23055 12 ChenY.MiY.ZhangX.MaQ.SongY.ZhangL.et al (2019)
Counts for genes of interest were normalized to derive expression values while accounting for potential differences in library size or read length bias
