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3.5 Dysregulated collagen metabolism In parallel to various signaling cascades, dysregulation in collagen metabolism and homeostasis also contributes to OSFs pathogenesis (Cabral-Pacheco et al., 2020), and LOX activity, which is responsible for the intra- and inter-molecular cross-linking of non-degradable (proteolytic degradation) collagen fibrils ( OSF histological progression can be categorized into four stages based on collagen formation and accumulation, which include (i) very early, (ii) early, (iii) moderately advanced, and (iv) advanced

10.1016/j.biochi.2010.06.009 62 KimK.PortisJ

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WieseSEsatbeyogluTWinterhalterPKruseHPWinklerSBubAet alComparative biokinetics and metabolism of pure monomeric, dimeric, and polymeric flavan-3-ols: A randomized cross-over study in humans