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Furthermore, pharmacologically induced PIEZO1 activation (through Yoda1), combined with mechanical stretch, upregulates Lox expression in tendon fascicle explants

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It may result from nickel contamination in the copper alloy or from irritant reactions unrelated to immune activation

Receptor proximal assays can include cAMP response measurements, calcium flux assays where applicable, recruitment assays that track pathway engagement, and internalization or trafficking readouts that inform residence and persistence